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    云南民族大學學報(自然科學版)

    2020, v.29;No.124(06) 541-548

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    中藥有效成分干預潰瘍性結腸炎的機制研究
    Mechanism of active constituents of traditional Chinese medicine in ulcerative colitis

    李婷;鄒秋萍;何紅平;王亭;黃豐;李艷平;
    LI Ting;ZOU Qiu-ping;HE Hong-ping;WANG Ting;HUANG Feng;LI Yan-ping;School of Chinese Medicine, Yunnan University of Traditional Chinese Medicine;

    摘要(Abstract):

    潰瘍性結腸炎(ulcerative colitis,UC)為1種病因不明且易反復發作的慢性非特異性腸道疾病,由環境因素、遺傳、腸道微生物失調、粘膜和上皮屏障功能異常以及免疫失調等因素所致.其臨床癥狀主要為腹痛、腹瀉、黏液膿血便等.治療藥物主要以氨基水楊酸類、皮質類固醇、免疫抑制劑等為主,但這些藥物可能有不同的副作用,甚至嚴重的不良反應,中藥具有安全系數高、毒副作用少等優點,而起作用的主要為其有效成分.綜述概括了中藥有效成分通過6種信號通路(TLR4/MyD88/NF-κB、NLRP3、PPARγ/NF-κB、MAPK、Treg/Th17、JAK2/STAT3)治療潰瘍性結腸炎的研究進展,為中藥開發以及其對潰瘍性結腸炎的機制研究提供了新的思路.
    Caused by multiple factors such as environmental factors, heredity, intestinal microbiological disorders, mucosal and epithelial barrier dysfunctions and immune disorders, ulcerative colitis(UC) is a recurrent, chronic non-specific intestinal inflammatory disease whose etiology is not very clear. UC patients have the clinical symptoms such as abdominal pain, diarrhea, tenesmus, mucus, pus and blood in the stool, etc. The main therapeutic drugs are the aminosalicylic acid, corticosteroids, immunosuppressive agents, etc. However, these drugs may have different side effects and even serious adverse reactions. Traditional Chinese medicine has long been used in treating UC with the advantages of a higher safety level and less side effects. Therefore, this review summarizes the research progress of traditional Chinese medicine on UC through six main signaling pathways(TLR4/MyD88/NF-κB, NLRP3, PPARγ/NF-κB, MAPK, Treg/Th17, JAK2/STAT3) in order to provide new ideas for the development of traditional Chinese medicine and clarify its mechanism on ulcerative colitis.

    關鍵詞(KeyWords): 潰瘍性結腸炎;中藥有效成分;信號通路
    ulcerative colitis;active constituents of traditional Chinese medicine;signaling pathway

    Abstract:

    Keywords:

    基金項目(Foundation): 國家自然科學基金(81960777,81660717,31760100,81760745);; 云南省應用基礎研究項目(2019FF002(-005),2017FB133);; 云南省教育廳科學研究基金(2019Y0332)

    作者(Author): 李婷;鄒秋萍;何紅平;王亭;黃豐;李艷平;
    LI Ting;ZOU Qiu-ping;HE Hong-ping;WANG Ting;HUANG Feng;LI Yan-ping;School of Chinese Medicine, Yunnan University of Traditional Chinese Medicine;

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